Hydrophilic hybrid IPNs of segmented polyurethanes and copolymers of vinylpyrrolidone for applications in medicine

ABRAHAM,G.A.; DE QUEIROZ,A.A.A.; SAN ROMAN,J

BIOMATERIALS

Elsevier Science, LTd.

Lugar: Oxford, U.K.; Año: 2001 vol. 22 p. 1971 - 1985

0142-9612

The preparation and biocompatibility properties of thermoplastic apparent Interpenetrating Polymer Networks (T-IPNs) of a segmented polyurethaneurea, Biospan™ (BS), and vinylpyrrolidone-dimethylacrylamide (VP-DMAm) copolymers, are described.  The biological interaction between the obtained  materials and blood was studied by in vitro methods.  The addition of the VP-DMAm copolymers to form T-IPNs with BS substantially increased the equilibrium water uptake and water diffusion coefficients.  Investigation of the proteins adsorption, platelet adhesion, thrombus formation and factor XII activation is presented.  Investigations of the proteins adsorption of the BS/VP-DMAm T-IPNs surfaces show  that the segmented polyurethane (BS) containing VP-DMAm copolymers with higher VP content adsorb more albumin than fibrinogen and  g-globulin.  The platelets adhesion, thrombus formation and factor XII activation are effectively suppressed  respect to the segmented polyurethane when VP-DMAm copolymers with high VP contents are incorporated to BS  as T-IPNs. Keywords: segmented polyurethanes, thermoplastic IPNs, VP-DMAm, blood compatibility, proteins adsorption.