Electrohydrodynamic Techniques for the Manufacture and/or Immobilization of Vesicles

SÁNCHEZ-CERVIÑO, MARÍA CELINA; FUIOAGA, CODRIN PAUL; ATANASE, LEONARD IONUT; ABRAHAM, GUSTAVO A.; RIVERO, GUADALUPE

Polymers

MDPI

Lugar: Basel; Año: 2023 vol. 15 p. 795 - 813

The development of accurate drug delivery systems is one of the main challenges in thebiomedical field. A huge variety of structures, such as vesicles, nanoparticles, and nanofibers, havebeen proposed as carriers for bioactive agents, aiming for precision in administration and dosage,safety, and bioavailability. This review covers the use of electrohydrodynamic techniques both forthe immobilization and for the synthesis of vesicles in a non-conventional way. The state of theart discusses the most recent advances in this field as well as the advantages and limitations ofelectrospun and electrosprayed amphiphilic structures as precursor templates for the in situ vesicleself-assembly. Finally, the perspectives and challenges of combined strategies for the development ofadvanced structures for the delivery of bioactive agents are analyzed.