INVESTIGADORES
BALLARRE josefina
artículos
Título:
Morphologic and nanomechanical characterization of bone tissue growth around bioactive solgel coatings containing wollastonite particles applied on stainless steel implants
Autor/es:
JOSEFINA BALLARRE; ROCIO SELZER; EMIGDIO MENDOZA; JUAN CARLOS ORELLANO; YIU-WING MAI; CLAUDIA GARCÍA; SILVIA M. CERÉ
Revista:
MATERIALS SCIENCE & ENGINEERING. C, BIOMIMETIC MATERIALS, SENSORS AND SYSTEMS
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2011 vol. 31 p. 545 - 552
ISSN:
0928-4931
Resumen:
Metals are the most widely used materials in orthopaedic and dental implants due to their excellent
mechanical properties. However, they do not bond naturally with mineralized bone. Further, they can release
metallic particles that may finally result in the removal of the implant. There are two strategies to avoid these
drawbacks: one is to protect the metallic implant with a biocompatible coating and the other is to add
bioactive particles to enhance implant fixation to the existing bone. In this work, surgical grade stainless steel
implants coated with tetraethoxysilane (TEOS)methyltriethoxysilane (MTES) and 10 wt.% of commercial
wollastonite particles were implanted in the Hokkaido femur rats. Transversal sections of the tibia samples
were examined with SEM, AFM, histological analysis and nanoindentation experiments in air and under
physiological conditions to characterize the hydroxyapatite deposits and the composition of the newly
formed tissue around the implant. The results showed no presence of harmful ions or metallic particles in the
surrounding tissues and that the coating promoted formation and growth of new bone in the periphery of the
implant, both in contact with the old bone (remodellation zone) and the marrow (new bone). The relative
mechanical behavior of old, remodeled and new bone tissues obtained in air cannot be directly extrapolated
to live or in vivo-physiological response. This may be caused by the different degree of hydration and SBF/
structure interaction among the three types of bones but these values are near the normal hydrated bone
response.