Copper handling in the Salmonella cell envelope and its impact on virulence

CHECA, SUSANA K. (CORR. AUTHOR); GIRI,GERMÁN F.; ESPARIZ, MARTÍN; ARGÜELLO, JOSÉ M.; SONCINI, FERNANDO C.

TRENDS IN MICROBIOLOGY

ELSEVIER SCIENCE LONDON

Lugar: Londres; Año: 2021

0966-842X

Copper (Cu) plays a key role at the host-pathogen interface, both as an essential and a toxic element. Intracellular pathogenic Salmonella have acquired the periplasmic Cu chaperone CueP and the thiol oxidoreductases complex Scs, while losing the ancestral Cu-detoxification Cus system. Co-regulation of these species-specific factors link Cu with redox stress and allows Salmonella to counteract Cu toxicity during infection.