INVESTIGADORES
ALDANA Ana agustina
artículos
Título:
Chitosan films modified selectively on one side with dendritic molecules
Autor/es:
ALDANA A.; TOSELLI R.; STRUMIA M.; MARTINELLI M.
Revista:
JOURNAL OF MATERIALS CHEMISTRY
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Lugar: CAMBRIDGE; Año: 2012 p. 22670 - 22677
ISSN:
0959-9428
Resumen:
Novel chitosan films dendronized on one side were prepared by reaction between a cross-linked
biopolymer and weisocyanate dendron. According to ATR-FTIR analysis, it can be concluded that the
dendronization took place on only one of the faces of the films. The highlight of this work is that the
modification grants different hydrophilic and hydrophobic properties on both sides of the system.
Interactions between the dendron-polymer network and the hydrophobic characteristics of the dendron
modify the physical properties of the films. As the thermal stability of the films increases, the degree of
swelling and WVP values decrease, and the elastic modulus increases, turning the network more rigid.
The dendronized films were swollen at pH 3.4 and 6.8 which are the pHs of the different wound healing
stages. The films remained stable for an extended period. The films obtained can be potentially applied
as wound dressings able to maintain a moist environment at the wound interface and act as a barrier to
microorganisms, removing excess exudates. The product is made from a readily available biomaterial
that requires minimal processing, possesses antimicrobial properties and could promote wound
healing.