Dopaminergic isoquinolines with hexahydrocyclopenta [ij]-isoquinolines as D2-like selective ligands.

ROJAS, SEBASTIÁN; PARRAVICINI, OSCAR; GARIBOTTO, FRANCISCO MATIAS; ANDUJAR, SEBASTIAN ANTONIO

San Miguel de tucumán

Congreso; XLV Reunión Anual de la Sociedad de Biofísica; 2016

Dopamine receptors (DR) ligands are potential drug candidates for treating neurological disorders including schizophrenia or Parkinson?s disease. Three series of isoquinolines: (E)-1-styryl-1,2,3,4-tetrahydroisoquinolines (series 1), 7-phenyl 1,2,3,7,8,8a-hexahydrocyclopenta [ij]-IQs (HCPIQs) (series 2) and (E)-1-(prop-1-en-1-yl)-1,2,3,4- tetrahydroisoquinolines (series 3), were prepared to determine their affinity for both D1 and D2 -like DR. The effect of different substituents on the nitrogen atom (methyl or allyl), the dioxygenated function (methoxyl or catechol), the substituent at the b -position of the THIQ skeleton, and the presence or absence of the cyclopentane motif, were studied.