Dendritic cell maturation and cross-presentation: timing matters!

ALLOATTI, ANDRÉS; KOTSIAS, FIORELLA; MAGALHAES, JOAO; AMIGORENA, SEBASTIAN

IMMUNOLOGICAL REVIEWS

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2016 vol. 272 p. 97 - 108

0105-2896

As a population, dendritic cells (DCs) appear to be the bestcross-presenters of internalized antigens on major histocompatibilitycomplex class I molecules in the mouse. To do this, DCs have devel-oped a number of unique and dedicated means to control their endo-cytic and phagocytic pathways: among them, the capacity to limitacidification of their phagosomes, to prevent proteolytic degradation,to delay fusion of phagosomes to lysosomes, to recruit ER proteins tophagosomes, and to export phagocytosed antigens to the cytosol. Theregulation of phagocytic functions, and thereby of antigen processingand presentation by innate signaling, represents a critical level of inte-gration of adaptive and innate immune responses. Understanding howinnate signals control antigen cross-presentation is critical to defineeffective vaccination strategies for CD8+ T-cell responses.