Predictors of poor long-term renal prognosis in children with Hemolytic Uremic Syndrome

LAURA ALCONCHER; LUCAS LUCARELLI; M. RIVERO; EDGARDO MARIO RODRÍGUEZ

PEDIATRIC NEPHROLOGY

SPRINGER

Lugar: Berlin; Año: 2016 vol. 31 p. 1742 - 1742

0931-041X

Approximately 50% of hemolytic uremic syndrome (HUS) patients evolved to different stages of chronic kidney disease (CKD). More days of anuria imply a worse long term renal prognosis. Our aim was to look for predictors of poor renal outcome. Methods: Observational, longitudinal and retro-prospective study. HUS patients associated with diarrhea and at least 5 years of follow-up were included. To evaluate long term renal outcome, patients were divided in 3 groups: No sequelae, CKD stage 1 and CKD stage 2-5. Predictors analyzed included: gender, age at onset(20000), days of dialysis (0, 1-9 and ≥10), initial hematocrit (≤23 or >23 %), and red blood cells (RBC) transfusion requirement. A bivariate and multivariate analysis were performed, a p20000 and hematocrit >23% were significant CKD predictor only in the bivariate analysis (p=0.04 and p=0.0049).The risk to evolve to CKD stages 2-5 was similar in patients who did not required dialysis to those with < 10 days(p=0.31).CKD risk increase 8.8 (CI 95% 4.1-18.5) and 3.2 (CI 95% 1.6-6.3) times in patients with ≥ 10 days of dialysis and those with no RBC transfusion requirement respectively (p