INVESTIGADORES
MUSSO Carlos Guido
artículos
Título:
Oxcarbazepine induced hyponatremia: a potential explanation of its physiopathology.
Autor/es:
MUSSO, CARLOS GUIDO; VILAS, MANUEL; APARICIO, CAROLINA; BEVIONE, P.; REYNALDI, JULIANA; ROJAS, J.; JAUREGUI, JOSE R.; ALGRANATI, LUIS
Revista:
Electron J Biomed
Editorial:
MJ Coma MD, PhD. Unidad de Investigación. Hospital General Yagüe
Referencias:
Año: 2009
Resumen:
Carbamazepine and oxcarbazepine are antiepileptic drugs which can induce hyponatremia, being this disorder more frequent with the latter.In this report we present a clinical case regarding an oxcarbazepine induced hyponatremia, and we hypothesized that oxcarbazepine could induce hyponatremia as a consequence of its influence on distal nephron where it could promote free waterretention, urinary sodium loss, or both of them.Besides, we proposed that a greater tubular sesitivity to oxcarbazepine than to carbamazepine could explain the different hyponatremia inducing capability between these two drugs.
