Free Water Clearance: Its Behavior in Chronic Renal Disease at Different Ages

MUSSO CG

Saudi J Kidney Dis Transpl

Medknow

Año: 2011

1319-2442

To the Editor, One of the known renal physiologic alterations described in Chronic Renal Disease (CRD) is a reduction in free water clearance (FWC).1 It has also been described in the literature that there is a reduction of FWC in the healthy aged kidneys compared to the younger ones.2 However, there are no reports describing whether FWC is more reduced in the elderly CRD patients. Thus, we decided to conduct a prospective study in order to try and get an answer to the above-mentioned factor. We studied FWC in 58 patients with CRD who were divided into four groups: 10 young patients (20?40 years) with CRD stage-2, 5 young patients (20?40 years) with CRD stage- 3, 17 elderly patients (older than 64 years) with CRD stage-2 and 26 elderly (>64 years) patients with CRD stage-3. Exclusion criteria included presence of cardiac failure, arrhythmia, hypothyroidism, cirrhosis and use of non-steroidal anti-inflammatory drugs, diuretics and psycho-neurological medications.