Magnesium handling in peritoneal dialysis patients with preserved residual diuresis

MUSSO, CARLOS G.; TRIGKA, KONSTANTINA; DOUSDAMPANIS, PERIKLIS

INTERNATIONAL UROLOGY AND NEFROLOGY

Springer Netherlands

Año: 2016 vol. 48 p. 633 - 634

0301-1623

Editor,There is increasing evidence supporting an association between serum magnesium levels and many clinical disorders, such as: chronic kidney disease (CKD) progression, dyslipidemia, hypertension, insulin resistance, atherosclerosis, endothelial dysfunction, inflammation, oxidative stress, vascular calcification, ventricular cardiac arrhythmias, hyperaldosteronism, and intradialytic hypotension [1, 2, 3, 4]. Moreover, hypomagnesemia (≤1.5 mg/dL) has also been associated with an increased mortality risk in CKD patients [3]. However, we noticed that although there is currently a lot of information delivered in the literature regarding magnesium (Mg) handling in hemodialysis patients, there is not much information about this topic in peritoneal dialysis population [4, 5, 6, 7, 8, 9]. Thus, we decided to report in this letter what we have documented regarding Mg handling in our peritoneal dialysis unit [10]. We studied Mg levels in serum, urine, and peritoneal fluid samples in 22 adult peritoneal dialysis patients who had preserved their residual diuresis. These patients had the same type of peritoneal membrane (average), glucose (2.3 %), and Mg (0.75 mmol/L) concentration in their peritoneal dialysis bags, prescribed dialysis scheme, residual glomerular filtration rate (GFR): 9 ± 0.5 mL/min/1.73 m2, and diet. From these data, fractional excretion of Mg in urine and peritoneal fluid was obtained. In this study, we documented that serum Mg was normal in all the evaluated patients (2.3 ± 0.5 mg/dL), and fractional excretion of Mg was significantly higher in peritoneal fluid (36 ± 6 %) than in urine (30 ± 5 %), p value