BECAS
VELÁZQUEZ LÓPEZ Daniela Alejandra
congresos y reuniones científicas
Título:
In vitro study of Amphotericin-B and Clomipramine combination upon Leishmania brazilensis
Autor/es:
STRAUSS, MARIANA; LOZANO, ESTEBAN ; AGUILAR, J; KONIGHEIM, B; AMELIA, E; LO PRESTI, SILVINA; BAZAN, CAROLINA; BAEZ, ALEJANDRA; VELÁZQUEZ LÓPEZ, DANIELA; PAGLINI, PATRICIA; RIVAROLA, WALTER
Lugar:
Buenos Aires
Reunión:
Congreso; Reunión Conjunta de Sociedades de Biocoencias; 2017
Institución organizadora:
Sociedades de Biocencias
Resumen:
urrent drugs for the treatment of Leishmaniasis show disadvantages due to toxicity and high cost. Among these, Amphotericin-B (AMPHO), which causes the death of the parasites due to alterations in their cell membranes, also has adverse effects upon the host. Consequently, the search for new drugs, focused on molecular targets that are present in the parasite but absent in the host, continues. Clomipramine (CLO) is a potent inhibitor of trypanothione reductase, an enzyme exclusive to the Kinetoplastida order.
