Incidence of hospital-acquired venous thromboembolic disease among clinical and surgical inpatients

POSADAS-MARTINEZ, MARIA LOURDES; MARIA GRANDE-RATTI; JIMENA VICENS; FERNAN QUIROS; FERNAN QUIROS; FERNANDO VAZQUEZ

THROMBOSIS RESEARCH

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2016 vol. 141

0049-3848

Background: Venous thromboembolism (VTE) is still a common, sometimesfatal, and potentially preventable medical problem in hospital settings.Our aim was to estimate the crude incidence rate (IR) and adjusted bystandardization of VTE developed during hospitalization, in clinical andsurgical inpatients.Methods: Prospective cohort of all adult clinical and surgical inpatients,admitted to the hospital between 2006 and 2013. VTE incident cases werecaptured prospectively from the Institutional Registry of ThromboembolicDisease in a tertiary hospital care in Buenos Aires. Follow-up was untildischarge or death. The IR was calculated for inpatients according to thenumber of incident cases of an initial VTED episode per 1,000 persondays.The rates were adjusted by direct standardisation to the age and sexdistribution of the populations of Argentina and Buenos Aires according tothe 2010 Census, as well as in relation to the European standard population.We also conducted a Poisson regression model to evaluate the determinantsof VTE and adjusted for the following variables: age category, sex andsurgical admissions. Incidence rate ratios (IRRs) were obtained for thismodel with 95% confidence intervals.Results: The crude incidence rate of VTE for clinical patients was 0.49 (CI95%0.45-0.55) per 1,000 person-days, and IR adjusted for Argentina was 0.23(CI95% 0.20-0.27). The crude IR of VTE for surgical patients was 0.25 (CI95%0.23-0.27), and IR adjusted for Argentina was 0.14 (CI95% 0.10-0.17). The IRratio for VTE when adjusted for age category, sex and surgical admissions:Surgical admissions reduce the IRR by 40%; and the thrombosis rate riskincreases across age categories, being 8 times higher for older than 80 yearsthan