Platelet volume as a prognostic factor of pulmonary thromboembolism

POSADAS-MARTINEZ, MARIA LOURDES; JUAN DIAZ; BIOETTI, BRUNO; FERNAN QUIROS; VERONICA PEUCHEOT; FERNANDO VAZQUEZ

THROMBOSIS RESEARCH

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2016 vol. 141

0049-3848

Background: Pulmonary embolism (PE) is a frequent and with a fatalityrate of 5-10%. Mean platelet volume (MPV) is a risk factor for cardiovascularcomplications and cerebrovascular disorders, and inflammatory conditions.Our aim is to evaluate the association between high VPM and 90-daysurvival after a PE episodeMethods: Prospective cohort of all consecutive adult patients witha first episode of PE were included in the Institutional Register ofThromboembolism (Institutional Registry of Thromboembolic.-Home-ClinicalTrials.gov, NCT01372514) between 2014 and 2015, in the Hospital Italiano, Buenos Aires, Argentina. MPV was evaluated during the PE eventand follow-up was until 90 days or death. MPV was considered high if >11 fL. Survival was estimated with Kaplan Meier. Cox regression was usedto evaluate MPV and death, crude (HRc) and adjusted hazard ratios (HRa)were reported.Results: We included 147 patients, with a median age of 73 years, 57% werefemale. The main comorbidities were: 49% cancer, 15% coronary disease,15% sepsis and 10% stroke. Median MPV was 8 fl (8- 10), serum troponin22.5 pg/ml (12- 50), proBNP 1055 pg/ml (298-2600). Prevalence of highMPV was 17% (25). Overall mortality was 22.4% (33). 7 day survival estimatewas 0.88 (95%CI 0.67-0.95) vs 0.97 (95%CI 0.91-0.99); 30 day survival0.64 (95%CI 0.42-0.79) vs. 0.91 (95%CI 0.85-0.95); and 90 day survivalestimate was 0.52 (95%CI 0.31-0.69) vs. 0.82 (0.74-0.88) for high MPV andnormal MPV respectively. Overall survival estimate was statically different(p