INVESTIGADORES
MARCIANO Sebastian
artículos
Título:
Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in a multiethnic population
Autor/es:
JULIETA TRINKS; NISHIDA N; HULANIUK ML; CAPUTO M; TSUCHIURA T; SEBASTIAN MARCIANO; HADDAD L; BLEJER J; ADRIAN GADANO; MIZOKAMI M
Revista:
LIVER INTERNATIONAL
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2017
ISSN:
1478-3223
Resumen:
BACKGROUND & AIMS:HBV infection exhibits geographical variation in its distribution in South America. While HBV rates are low in central Argentina, the north-western region exhibits intermediate HBV rates. Unfortunately, the reasons that could explain this difference are still unknown.METHODS:A total of 1440 Argentines were recruited and grouped into HBV patients, HBV-resolved individuals and healthy controls. Genetic ancestry was assessed by analysis of biparental lineages and ancestry autosomal typing. SNPs of HLA-DPA1 (rs3077), HLA-DPB1 (rs9277542), HLA-DQB1 (rs2856718) and HLA-DQB2 (rs7453920) were determined, and HBV genotyping was performed by phylogenetic analysis in HBV patients.RESULTS:Native American ancestry prevailed in the north-western region when compared with central Argentina (P
