Antioxidant and antimicrobial activity of red propolis embedded mesoporous silica nanoparticles

AZEVEDO DE M. OLIVEIRA, LAÍS F.; TELES DA SILVA, LAIS VANESSA DE AZEVEDO; DO NASCIMENTO, TICIANO G.; DE ALMEIDA, LARA MENDES; CALUMBY, RODRIGO JOSÉ NUNES; NUNES, ÁBNER MAGALHÃES; DE MAGALHÃES OLIVEIRA, LEONARDO MENDONÇA TENÓRIO; DA SILVA FONSECA, EDUARDO J.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

TAYLOR & FRANCIS INC

Año: 2020 vol. 46 p. 1199 - 1208

0363-9045

This work brings the promise of MCM-41 mesoporous silica as a vehicle for red propolis for the development of controlled release drugs and delivery to a specific target site. The synthesis of MCM-41 by the sol?gel method with a pore size of approximately 3.6 nm and the incorporation of red propolis extract by the physical adsorption method in ethanolic medium were easily accomplished with around 15% encapsulation. MCM-41 and MCM-41 with red propolis (MCM-41/Pr) were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermal analysis, N2 adsorption?desorption, scanning electron microscopy, and an ultra-high-performance liquid chromatography?diode array detection (UPLC-DAD). In vitro release of encapsulated red propolis was analyzed in phosphate buffer at pH 7.2, 7.4, and 7.6. An in vitro test for MCM-41/Pr antioxidant activity was performed using 2,2-diphenyl-1-picrylhydrazyl as well as analysis of antibacterial activity against Staphylococcus aureus by the well diffusion method. UPLC-DAD analysis showed that the integrity of the red propolis constituents was maintained after the embed process, and the antioxidant and antibacterial activities were preserved.