Hierarchical Structured Collagen Biomaterial with Controlled Antimicrobial Activity

MUNICOY , SOFIA; ANTEZANA PABLO EDMUNDO; PEREZ, CLAUDIO; BELLINO , MARTIN; DESIMONE, MARTIN FEDERICO

Conferencia; UK-Poland Bioinspired Materials Conference; 2020

The development of advanced biocidal systems stands as a global challenge, focused on the increasing demand of new antimicrobial biomaterials. This is the first time that three well-known materials are strategically combined to develop a novel biomaterial with prolonged bactericidal activity that avoids explosive release and toxic effects, by the incorporation of silver nanoparticles in lipid vesicles and their subsequent incorporation in collagen gels. These assemblies show enhanced mechanical properties and sustained inhibitory effect on the growth of Gram-positive and Gram-negative bacteria, while remaining highly biocompatible for mammalian cells. In fact, the hybrid biocomposite prevents bacterial colonization for at least 72 hours, allowing at the same time eukaryotic cell proliferation. As a result, this novel new bactericidal biomaterial provides a new alternative to improve current treatments of bacterial infections with many implications in significant applications, such as wound therapy and tissue regeneration.