BECAS
LÓPEZ LÓPEZ Lina Vanessa
congresos y reuniones científicas
Título:
Complex hybrid systems of biological interest: synthesis of spiropyrrolidine-penicillins and spirooxindole-penicillin hybrids
Autor/es:
LÓPEZ LÓPEZ, LINA; MAGGIO, RUBÈN; MATA, ERNESTO; DELPICCOLO, CARINA
Lugar:
Rosario, Santa Fe
Reunión:
Congreso; VII Edición de la Reunión Internacional de Ciencias Farmacéuticas; 2023
Institución organizadora:
Universidad Nacional de Rosario
Resumen:
Hybrid molecules have the potential to reduce side effects and overcome drug resistance problems since they contain two or more different pharmacophores and may have multiple mechanisms of action.1 Several hybrid molecules are currently in clinical trials for the treatment of different diseases. Spirocompounds are characterized by their diverse activity, including FDA-approved drugs (e.g. MI-888).2 On the other hand, penicillins are structures of known antibiotic activity, described also for their antiviral, anticancer, anti-inflammatory and cholesterol absorption inhibitory activity.
