BECAS
ANGELONI Genaro
congresos y reuniones científicas
Título:
Relevance of Polypeptide GalNAc-transferase 3 in the human health
Autor/es:
IRAZOQUI, FERNANDO J.; GARAY, YOHANA C.; PARODI, PEDRO; FERRERO, FRANCO ALEJANDRO; ANGELONI, GENARO
Lugar:
Mar del Plata
Reunión:
Congreso; Reunión conjunta SAIC SAI & FAIC SAFIS 2022; 2022
Institución organizadora:
Sociedad Argentina de Investigación Clínica
Resumen:
Polypeptide GalNAc-transferase 3 (ppGalNAc-T3) is an enzyme involved in the initiation of O-GalNAc glycan biosynthesis. Acting as a writer of frequent post-translational modification (PTM) on human proteins, ppGalNAc-T3 has key functions in the homeostasis of human cells and tissues. This molecule has relevant roles in the biosynthesis of O-GalNAc glycans, as well as in biological functions related to human physiological and pathological conditions. With main emphasis in ppGalNAc-T3, we draw attention to the different ways involved in the modulation of ppGalNAc-Ts enzymatic activity. In addition, different subcellular localizations of ppGalNAc-T3 are represented, highlighting critical intrinsic and extrinsic functions in cellular physiology that are exerted by ppGalNAc-T3-synthesized PTMs. Moreover, we update on several human pathologies associated with dysfunctional ppGalNAc T3. Finally, biotechnological tools as new therapeutic options for the treatment of pathologies related to altered ppGalNAc-T3 are considered.