Characterization of the subfamilies TcTASV-B and TcTASV-W in different T. cruzi strains.

RIZZI, MARIANA; MASIP, YAMIL E.; TEKIEL, VALERIA

Buenos Aires

Congreso; I Reunión Conjunta de Sociedades de Biociencias; 2017

Sociedad Argentina de Parasitología

TcTASV is a Trypanosoma cruzi multigene family comprising about ~40 members and without orthologs in other trypanosomatids. All protein products of the TcTASV family have conserved amino and carboxy-termini, and a central variable core that allows partitioning TcTASV into four subfamilies: A, B, C and W. TcTASV-A and TcTASV-C subfamilies are the most numerous and were already characterized by our group (García, et al 2010; Bernabó et al 2013; Floridia et al 2016) but little is known about the less numerous TcTASV-B (2-10 genes) and TcTASV-W (2-4 genes) subfamilies. To characterize TcTASV-B and W subfamilies we carried out genomic and protein expression studies.