Heat Shock Proteins 90 kDa: Immunomodulators and Adjuvants in Vaccine Design Against Infectious Diseases

CORIGLIANO, MARIANA G.; SANDER, VALERIA A.; RAMOS DUARTE, VICTOR A.; SANCHEZ E; MENDOZA L.F; CLEMENTE, MARINA

Frontiers in Bioengineering and Biotechnology

Frontiers Media S.A.

Año: 2021 vol. 8 p. 1 - 19

2296-4185

Heat shock proteins 90 kDa (Hsp90s) were originally identified as stress-responsiveproteins and described to participate in several homeostatic processes. Additionally,extracellular Hsp90s have the ability to bind to surface receptors and activate cellularfunctions related to immune response (cytokine secretion, cell maturation, and antigenpresentation), making them very attractive to be studied as immunomodulators. Inthis context, Hsp90s are proposed as new adjuvants in the design of novel vaccineformulations that require the induction of a cell-mediated immune response to preventinfectious diseases. In this review, we summarized the adjuvant properties of Hsp90swhen they are either alone, complexed, or fused to a peptide to add light to theknowledge of Hsp90s as carriers and adjuvants in the design of vaccines againstinfectious diseases. Besides, we also discuss the mechanisms by which Hsp90s activateand modulate professional antigen-presenting cells.