BECAS
HERMIDA ALAVA Katherine Stefania
artículos
Título:
High Prevalence of triazole-resistant Aspergillus fumigatus sensu stricto in an Argentinean cohort of patients with cystic fibrosis
Autor/es:
TOMÁS BRITO DEVOTO; KATHERINE HERMIDA-ALAVA; GLADYS POSSE; JORGE L. FINQUELIEVICH; GUILLERMO GARCÍA-EFFRÓN; MARÍA L. CUESTAS
Revista:
MYCOSES
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Lugar: Londres; Año: 2020
ISSN:
0933-7407
Resumen:
Triazole resistance in Aspergillus fumigatus due to mutations in the cyp51A gene has been widely reported. Data from Argentina, and particularly from cystic fibrosis (CF) patients, are limited. This study aimed to investigate the prevalence and molecular mechanisms of azole resistance in A. fumigatus recovered from this population. Results showed that 14% of isolates displayed high MIC values to at least one azole. Of them, 30.7% had the mutation TR34-L98H. No mutations in the cyp51A gene or its promoter were found in the remaining non-wild type strains. Therefore, other mechanisms associated with azole resistance can be highly prevalent in these isolates.
