Undaria pinnatifida (Alariaceae), an allochthonous brown seaweed from the Golfo San Jorge (Patagonia Argentina)

QUEZADA DIANA PAULA; NAMUNCURÁ MARÍA SOLEDAD; ESCOBAR DAZA MIRIAM D; CORDOBA OSVALDO LEON; FLORES MARIA LUJAN

Córdoba

Congreso; 6ta Reunión Internacional de Ciencias Farmacéuticas (RICiFa 2020+1); 2021

There are many antecedents showing Undaria pinnatifida as a potential source of bioactive metabolites throughout the world. In this context, the aim of this work was to analyze the chemical composition and biological activity of the algae collected in autumn in the Golfo San Jorge (45°57' 41,8" S, 67° 33' 20.9" W). The fronds were dried, grounded and exhaustively extracted by different methodologies, obtaining EOH1, EOH2, EUpOMeOH. They were analyzed by chemical screening, planar and gas chromatography; the biological activities were evaluated by determination of cytotoxicity against Artemia salina and antibacterial activity against typified bacterial strains. The main metabolites were phenolic acids (caffeic, ferulic), flavonoids (cacticin, quercitrin), tannins, lipids (mono and diglycosylglycerides, fatty acids, cholesterol), steroids, triterpenes, carbohydrates (mannitol, monosaccharides), cardiotonic glycosides (k-strophanthoside and convalatoxin type). The extracts showed outstanding cytotoxicity with an LD50 of 16.75 and 312.20 µg/ml for EOH2 and EUpOMeOH, respectively. Antibacterial activity was negative. Our results show a complex chemical composition coinciding with that indicated for other countries, although the determined flavonoids and cardiotonic had not been reported for the species. The cytotoxicity evidenced presumes antitumor activity and is related to the determined metabolites, positioning U. pinnatifida as a promising source of products of pharmaceutical interest.