Hybrid System Supported on Bacterial Cellulose for Controlled Release of Bactericide Agents

LUIZA FERREIRA SOBRINHO; HORUE, MANUEL; CASTRO, GUILLERMO R; ISELI LOURENÇO NANTES

Simposio; VIII NanoMat; 2023

Nanociências a Materiais Avançados da UFABC

A wound is a disturbance of the tissue´´s standard shape and function. Skin disruption happens in skin lesions due to physical, thermal, or chemical damage or certain underlying medical or pathological conditions. Gram-positive, sphere-shaped bacteria such as Staphylococcus aureus are a significant health issue due to their multidrug resistance (MDR). Methods for delivering bactericides straight to incisions are being researched. Chemical and photochemical compounds such as safranin and phenothiazines are excellent options for attacking bacteria through chemical and photochemical mechanisms. However, the water solubility and rapid release restrict their effectiveness. In this study, a new hybrid biomaterial was created that combines bacterial cellulose (BC) hydrogel and cellulose nanofibers (CNF) for use as a local drug delivery implant for skin treatments using safranin, which has excellent antimicrobial action against Gram-positive bacteria. CNF increased the safranin load by around two times more than safranin only incubated in BC, indicating a kinetically controlled release mechanism. Bacterial cellulose was also efficient in adsorbing phenothiazine radical cation and its corresponding oligomer, which is promising for application in photodynamic therapy.