Organophosphorus Chemistry: Synthesis of new phosphonic acid derivatives bearing a triazole moiety

ESTEBAN ELOY BJERG; JOAQUÍN MARCHÁN GARCÍA; GABRIEL RADIVOY; YANINA MOGLIE; EDUARDO BUXADERAS

Conferencia; The 26th International Electronic Conference on Synthetic Organic Chemistry; 2022

A series of new 1,2,3-triazolylphosphonate were synthesized through the multicomponentalkyne-azide 1,3-dipolar cycloaddition catalyzed by copper nanoparticles on activated carbon. Thereactions were carried out in water and at a very low copper loading as green conditions, leading tothe triazolylphosphonate products in moderate to good yields. Studies about their activity as butyrylcholinesterase inhibitors are underway.