ORGANOPHOSPHORUS CHEMISTRY: SYNTHESIS OF NEW PHOSPHONIC ACID DERIVATIVES BEARING A TRIAZOLE MOIETY

ESTEBAN BJERG; JOAQUÍN F. MARCHÁN GARCÍA; GABRIEL RADIVOY; YANINA MOGLIE; EDUARDO BUXADERAS

Conferencia; The 26th International Electronic Conference on Synthetic Organic Chemistry; 2022

A series of new 1,2,3-triazolylphosphonates were synthesized through multicomponent alkyne-azide 1,3-dipolar cycloaddition catalyzed by copper nanoparticles on activated carbon. The reactions were carried out in water and at a very low copper loading as green conditions, leading to the triazolylphosphonate products in moderate to good yields. Studies into their activity as butyrylcholinesterase inhibitors are underway.