The combination of FSH and markers of Sertoli cell function provides a high accuracy strategy to differentiate central hypogonadism from constitutional delay of puberty in boys: a longitudinal prospective study

CASTRO, SEBASTIÁN; CORREA BRITO LOURDES; BELTRÁN BEDOGNI M.P.; ROPELATO, MARÍA GABRIELA; KESELMAN, ANA; CASSORLA FERNANDO; BERGADÁ, IGNACIO; REY, RODOLFO A.; GRINSPON, ROMINA P.

Congreso; 11th International Meeting of Paediatric Endocrinology (IMPE); 2023

Constitutional delay of puberty (CDP) and congenital central hypogonadism (CH) show great overlap in clinical features and in gonadotrophin and testosterone serum concentrations in boys. The gold standard to distinguish both entities relies on the assessment of pubertal stage beyond 18 years of age. The long lasting insufficient FSH activity in boys with congenital CH may result in lower AMH and inhibin B serum concentrations compared with boys with CDP.Aim of this study: to determine whether the assessment of the FSH-Sertoli cell axis could distinguish between CDP and CH in boys referred for pubertal delay. 62 boys with delay of puberty, median age at referral 14.2 years (CDP) and 15.3 years (CH), were prospectively evaluated until 18 years of age to ascertain the definitive diagnosis: CDP (n:32):testes >15 ml, CH (n:30): testes