Are albumin and white blood cells predictors of mortality in Status Epilepticus?

PACHA MARIA SOL; ORELLANA LUCAS; BONARDO P; ERNST GLENDA; MARTINEZ OSCAR; LAGGER IGNACIO

Houston

Congreso; 70th American Epilepsy Society Annual Meeting, www.aesnet.org; 2016

American Epilepsy Society

Rationale: Status Epilepticus (SE) is a neurological emergency and predicting outcome remains a challenge based only on clinical and electroencephalography findings. Actually, two validated clinical scoring systems as Status Epilepticus Severity Score (STESS) and Epidemiology-based Mortality score in Status Epilepticus (EMSE) are used to predict mortality. Albumin and white blood cells (WBC) have been postulated as pro-inflammatory markers of the outcome in SE.The aim of this study was to determine the associations between serum albumin level and WBC with outcome of SE. Methods: A retrospective study of 45 consecutive patients with SE admitted at Hospital Británico de Buenos Aires from 2009-2015. Evaluation of level of consciousness, age, worst seizure type, history of previous seizures, comorbidity, etiology and EEG were determinate to perform STESS and EMSE scores. Serum albumin levels and WBC were assessed at SE onset and 1 day after SE onset. To analyze data, we used GraphPad-prism 5 software and STATA-12 software. Relationship between survival and non-survival patients was calculated by Mann-Whitney test, and categorical variables were compared using Fisher test. P