Triggering Doxorubicin Release form pH-responsive Hydrogels Using the Concentration of Polyamines

CHÁVEZ, NÉSTOR A. PÉREZ; ALBESA, ALBERTO G.; LONGO, GABRIEL S.

San Luis

Congreso; SAB XLVIII; 2019

We present a molecular theory has been applied to study the equilibriumconditions of polyamines and doxorubicin adsorption in gels of poly-metacrilicacid (PMAA) for a drug delivery.This theory allows describing the charge and/or protonation, the shape, thesize and the configuration of each of the species that make up the system.The electrostatic nature of the adsorption of polyamines (and doxorubicin)causes non-monotonic behavior with respect to the pH. For the samereasons, the role of salt concentration is fundamental: by increasing theshielding charges of the other adsorbates, thus decreasing their adsorption.A systematic study covering of system properties (pH, salt concentrations,adsorbates concentrations) has performed.Preliminary results are indicators of a gel with capacities to transport drugsand release them by stimulation of polyamines: spermine, spermidine andputrescine. The gel adsorbs the latter and release the drug.The higher charge of polyamines displaces the adsorption of doxorubicin. Thehigh adsorptions are close to physiological pH.