5.8 MAPPING REGULATORY NETWORKS OF AUTISM RISK AT CELLULAR RESOLUTION DURING NEURODEVELOPMENT

MUHLE, REBECCA; NIU, WEI ; HILL-TERÁN, GUILLERMINA; YIM, KRISTINA; KRENZER, MARTINA; ABDALLAH, SARAH; KRISHNASWAMY, SMITA; NOONAN, JAMES

Washington, DC

Exposici�n; AACAP's 64th Annual Meeting; 2017

American Academy of Child & Adolescent Psychiatry

The complexity of the mechanisms underlying autism spectrum disorder (ASD) stands as a major obstacle to novel therapeutics development. ASD is a common neurodevelopmental disorder, typified by deficits in social communication and other behavioral symptoms. There are no available biological treatments to ameliorate the core ASD symptoms, in part due to the tremendous heterogeneity of genetic risk factors for ASD. There is a critical need to better understand the common and distinct neurological impacts of ASD risk genes to focus investigations for new therapeutics. To investigate ASD risk-associated regulatory networks with high temporal and spatial resolution, we have undertaken studies to globally map regulatory targets of ASD risk-associated chromatin modifiers at an early stage of human neurodevelopment, and in specific cell types and brain regions during mouse embryonic cortical development.