Decision-making in Parkinson’s disease patients with and without pathological gambling

MALCO ROSSI; ELIANA ROLDAN GERSCHCOVICH; DELFINA DE ACHAVAL; DANIEL CERQUETTI; MARIA INES NOUZEILLES; ANGEL CAMMAROTA; SANTIAGO PEREZ LLORET; RODOLFO FAHRER; MARCELO MERELLO; RAMON LEIGUARDA

Chicago

Congreso; American Academy of Neurology 60th Annual Meeting; 2008

American Academy of Neurology

Background and purpose: Pathological gambling (PG) in Parkinsons disease (PD) is a frequent impulse control disorder associated mainly with dopamine replacement therapy. As impairments in decision-making were described independently in PG and PD, the objective of this study was to assess decision-making processes in PD patients with and without PG. Methods: Seven PD patients with PG and 13 age, sex, education and disease severity matched PD patients without gambling behavior were enrolled in the study. All patients were assessed with a comprehensive neuropsychiatric and cognitive evaluation, including tasks used to assess decision-making abilities under ambiguous or risky situations, like the Iowa Gambling Task (IGT), the Game of Dice Task and the Investment Task. Results: Compared to PD patients without gambling behavior, those with PG obtained poorer scores in the IGT and in a rating scale of social behavior, but not in other decision-making and cognitive tasks. Conclusions: Low performance in decision-making under ambiguity and abnormal social behavior distinguished PD patients with PG from those without this disorder. Dopamine replacement therapy may induce dysfunction of the ventromedial prefrontal cortex and amygdala-ventral striatum system, thus increasing the risk for developing PG.