Motor features in Parkinson's disease with normal olfactory function

ROSSI, MALCO; ESCOBAR, ALEX MEDINA; BRIL, ANDREA; MILLAR VERNETTI, PATRICIO; DE PALO, JUAN IGNACIO; CERQUETTI, DANIEL; MERELLO, MARCELO

MOVEMENT DISORDERS

WILEY-LISS, DIV JOHN WILEY & SONS INC

Año: 2016 vol. 31 p. 1414 - 1417

0885-3185

Background: Normosmic Parkinson´s disease (PD) might be a unique clinical phenotype with a more benign course when compared with hyposmic PD. Objective: The objective of this study was to evaluate motor features and the acute levodopa response according to olfactory function. Methods: A total of 169 de novo PD patients that underwent olfactory testing and acute levodopa challenge for clinical prediction of sustained long-term dopaminergic response were evaluated. Results: The overall frequency of normosmia was 33%. Normosmic PD patients scored nonsignificantly different to hyposmic/anosmic patients on motor scale and on degree of improvement with levodopa. Motor scores at follow-up were comparable among groups. Conclusions: Normal olfactory function is common in early PD and was not associated with a different motor phenotype when compared with PD patients with olfactory dysfunction. © 2016 International Parkinson and Movement Disorder Society.