Extracellular Vesicles from dietary compound-stimulated Cancer-Associated Fibroblasts trigger cell proliferation on breast cancer cells

SOLLA ÉRICA DANIELA; ROLDAN GALLARDO, FRANCO FABIÁN; MAZO, TAMARA MAGALÍ; FERRERO, VICTORIA; PASQUALINI, MARÍA EUGENIA; MALDONADO, CRISTINA ALICIA; QUINTAR, AMADO

Santiago

Workshop; II Workshop Extracellular Vesicles in Biomedicine; 2023

Dietary patterns provided by carbohydrates- and saturated fatty acid-rich food (CAP and FAP), represented mainly by fructose (F) and palmitic acid (PA) respectively, is positively associated with the risk of breast cancer, with the cellular mechanisms being far to be fully elucidated. We aimed to evaluate the dietary effects on the microenvironment interactions between cancer-associated fibroblasts (CAFs) and tumoral cells, mediated by extracellular vesicles (EVs). Balb/c mice fed on CAP, FAP or CAP+FAP were s.c. implanted with LM3 mammary tumor cells. CAP+FAP tumors grew faster and with bigger volumes (p