tRNA-Derived Fragments As Potential New Biomarkers For Asthma Phenotyping

LEDIT ARDUSSO; JULIETA BELÉN GROSSO; MARÍA BELÉN MARAVAL; MATIAS ARDUSSO; CLARA CLAUS; SILVANA VIRGINIA SPINELLI

Congreso; XLIV Congreso Anual AAAeIC; 2021

The heterogeneous nature of asthma has been understood for decades, but this feature of the disease is becoming increasingly important in the era of specific biologic therapy. Unfortunately, accurate biomarkers for asthma phenotyping remain an unmet medical need. tRNA-derived fragments have been proposed as markers of different diseases and among them, tiRNA are of particular interest since they are produced under stress conditions.