BECAS
BACH Camila Agustina
congresos y reuniones científicas
Título:
Differential Glycosylation Controls the Immunoregulatory Activity of Myeloid-derived Suppressor Cells in Health and Cancer
Autor/es:
BACH CAMILA AGUSTINA; GABRIEL ADRIÁN RABINOVICH; ADA GABRIELA BLIDNER
Lugar:
San Martin
Reunión:
Simposio; GlycoAR 3rd Argentinian Symposium on Glycobiology; 2019
Institución organizadora:
Universidad Nacional de San Martín
Resumen:
DIFFERENTIAL GLYCOSYLATION CONTROLS THE IMMUNOREGULATORY ACTIVITY OF MYELOID DERIVED SUPPRESSOR CELLS IN HEALTH AND CANCERBach CA, Rabinovich GA, Bildner AG.Laboratory of Immunopathology, Institute of Biology and Experimental Medicine (IByME)-CONICET, Buenos Aires, Argentina.Myeloid Derived Suppressor Cells (MDSCs) are a heterogeneous population of immature myeloid cells that in pathologic conditions, become immunosuppressive. Since differential glycosylation may control the fate of distinct cell types by influencing binding of glycan-binding proteins, we investigated the glycosylation profile of MDSCs in normal conditions and cancer settings and their sensitivity to the lectin galectin-1 (Gal1). We found a differential glycosylation signature in Ly6g-Ly6chighCD11b+ cells, that showed higher non-silylated galactosyl (β-1,3) N-acetylgalactosamine branching (p
