3D Printed Nanocrystals for Oral Administration of the Drugs

LUCÍA LOPEZ VIDAL; DANIEL ANDRÉS REAL; ALEJANDRO PAREDES; JUAN PABLO REAL ; PALMA, SANTIAGO D.

Drug Delivery Using Nanomaterials

CRC press taylor & francis group

Año: 2021;

In the last 10 years, the number of poorly soluble drugs has steadily increased, and it is estimated that 90% of drugs in the discovery pipeline are facing solubility problems. Despite the enormous advantages of nanocrystals in improving the oral bioavailability of many drugs, few products currently use this technology. The conversion of these systems into solid dosage forms for oral administration is a challenge, as their physical stability could be compromised if conventional processes such as compaction are applied. Therefore, it is necessary to explore alternative technologies that allow the development of solid formulations based on nanocrystals without affecting their physicochemical properties. One of the strategies with the greatest potential are additive manufacturing methods, such as 3D printing.This chapter will discuss the challenges of oral drug delivery, how nanocrystals can contribute to overcoming these challenges and the opportunities generated by 3D printing in the production of pharmaceutical forms of nanocrystals for oral delivery.