GRAPE POMACE SUPPLEMENTATION ATTENUATES METABOLIC PARAMETERS IN SUBJECTS WITH OVERWEIGHT AND OBESITY

ASUS, N.; PERDICARO, DIAHANN J.; MUSCIA SAEZ MARIA VICTORIA; RODRIGUEZ LANZI, CECILIA; A. ANTONIOLLI; VAZQUEZ PRIETO, MARCELA A.

Congreso; ESPEN; 2021

Rationale: Grape pomace (GP) is a waste product obtained after the winemaking process, which contains relatively highamounts of bioactive compounds like polyphenols and dietary fiber. We previously showed that Malbec GPsupplementation improves metabolic parameters in rats with metabolic syndrome. The aim of this study was to evaluateweather GP supplementation could improve lipid profile and others metabolic parameters in overweight and obesesubjects. Methods: Subjects with body mass index (BMI) ≥ 27 were assigned to consume a granola enriched with 10 g of GP(containing 5.3 g of dietary fiber and 400 mg of phenolic compounds), for 6 weeks. Anthropometric and metabolicvariables were determined at the beginning and at the end of the experimental period. Data were analyzed using thestatistical GraphPad Prism version 5.00. Statistical significances were assessed by paired Student?s t test. Results: 10 subjects, age 38.8 ± 12.3 years, were included. Anthropometric and metabolic variables are shown in Table1. Supplementation with 10 g of malbec GP-enriched granola significantly reduced waist circumference, systolic bloodpressure, total cholesterol and LDL cholesterol levels. No significant differences were observed in body weight, BMI, HDLcholesterol, triglycerides, glycemia, insulinemia and CRP levels. Table 1. Effect of a 6 weeks supplementation with GP on anthropometric and metabolic parameters. Parameter Baseline End p SBP (mmHg) 119.0 ± 3.4 115.3 ± 3.3 0.040* Total cholesterol (mg/dl) 186.8 ± 11.3 171.1 ± 9.8 0.002* LDL cholesterol (mg/dl) 117.9 ± 11.0 105.3 ± 10.2 0.0006* Data are mean ± SEM.Difference between baseline values (0 weeks) and End values (6 weeks) were compared using a paired Student?s ttest (two-tailed). p values