EFFECT OF BIOACTIVE COMPOUNDS DERIVED FROM GRAPE POMACE ON OBESITY-RELATED KIDNEY INJURY

FIGUERAS TATIANA; GARCIA RODRIGO; PERDICARO, DIAHANN J.; MUSCIA SAEZ MARIA VICTORIA; CACCIAMANI VALERIA; VALLES PATRICIA; VAZQUEZ PRIETO, MARCELA A.; CONSTANTINO VALERIA

Congreso; REUNION ANUAL DE SOCIEDADES DE BIOCIENCIAS; 2022

Obesity is an important risk factor for the kidney disease development. Epidemiological studies have shown that the prevalence ofchronic kidney disease is increasing concomitant with obesity. Thephysiopathology of obesity-related kidney disease is multifactorial.Several mechanisms by which lipids can cause kidney damagehave been proposed, including inflammation, oxidative stress, andfibrosis. The intake of foods rich in bioactive compounds, such aspolyphenols attenuates pathologies associated with obesity andreduces inflammation and oxidative stress. Grape pomace extract(GPE) is obtained from grape pomace, a residue of the winemaking process. GPE is mainly constituted of berry skins and seeds,which still contain high amounts of phenolic compounds. Given thatin Mendoza, the wine industry each year generates great amountsof pomace, this can be used for implementing strategies in the prevention of obesity-associated pathologies