THE IL-17F rs763780 SNP IS ASSOCIATED WITH HUMAN TUBERCULOSIS SUSCEPTIBILITY AND DISEASE SEVERITY IN ARGENTINA.

AGUSTIN ROLANDELLI; JOAQUIN PELLEGRINI; CECILIA SANTILLI; NICOLAS AMIANO

CABA

Congreso; Reunión conjunta de sociedades de biociencias - LXV Reunión anual de la Sociedad Argentina de Inmunología (SAI); 2017

SAI

Mycobacterium tuberculosis (Mtb) causes nearly 10 millions of new tuberculosis disease cases annually. However, most individuals exposed to Mtb do not develop tuberculosis, suggesting the influence of a human genetic component. In this work, we investigated the association of the IL-17F rs763780 SNP (T→C), which generates a protein that is a natural IL-17F antagonist, with tuberculosis disease in Argentina. We found that individuals carrying the C allele were overrepresented in the TB population (TB N=201; HD N= 200; p