Effect of mild hyperthyroidism on glucocorticoid secretion induced by acute stress in pregnancy and lactating rats.

NEIRA FLAVIA JUDITH; PIETROBON ELISA OLIVIA; SÁNCHEZ MARÍA BELÉN; MORENO SOSA MARÍA TAMARA; SOAJE MARTA; JAHN GRACIELA ALMA; VALDEZ SUSANA

Otro; XXXVI Reunión Científica Anual de la Sociedad de Biología de Cuyo; 2018

Disorders in thyroid function are associated with anxiety and depression. Therefore, responses to stress may be altered in patients withthyroid diseases. Stress is associated with functional changes in brain areas such as the hippocampus (HpC) and medial basal hypothalamus(MBH) by activating the hypothalamic-hypophysis-adrenal axis (H-H-A) and the consequent release of glucocorticoids in response to thestressor. In this study we analyzed the effects of mild hyperthyroidism on corticosterone response (measured by RIA) to acute stress(exposure to ether vapors for 2 min.) and on the expression (by qPCR) of the glucocorticoid receptor (GR) and the long isoform of theprolactin receptor (PRLRL) in MBH and HpC in Wistar female rats in different reproductive states (day 19 of gestation (G19), 2 (L2) and12 (L12) of lactation). Hyperthyroidism (hyperT) was induced with T4 (0.1mg /kg/day, s.c.) a dose of that allows the maintenance oflactation. Control (Co) and hyperT rats were bled from the tail vein during the 2 min ether exposure (s1) and 5 min after ether exposure(s2). In G19 acute stress induced corticosterone release in Co group (P