BECAS
SCARAFIA Maria Agustina
congresos y reuniones científicas
Título:
CARDIAC KERNEL TRANSCRIPTION FACTOR NKX2-5 IS REGULATED BY A NOVEL SUPER-ENHANCER REGION IN PLURIPOTENT STEM CELL-DERIVED CARDIOMYOCYTES.
Autor/es:
MARIA AGUSTINA SCARAFIA; NICOLAS POSTEGUILLO; SHEILA LUCIA CASTAÑEDA; GUADALUPE AMIN; BELEN PALMA; ALAN MIQUEAS MÖBBS; JOAQUIN SMUCLER; CAROLINA COLLI; LUCIA NATALIA MORO; ARIEL WAISMAN; ALEJANDRO DAMIÁN LA GRECA; SANTIAGO GABRIEL MIRIUKA
Lugar:
Mar del Plata
Reunión:
Congreso; LXVII Reunion Anual de Sociedades de Biociencias; 2022
Institución organizadora:
Sociedad Argentina de Investigacion Clinica (SAIC)
Resumen:
The decisions to commit towards a cardiac cell fate are taken early during development. Defects in the cardiac program entail complications in cell specification and may lead to congenital heart diseases. Known as the cardiac kernel, TBX5, GATA4 and NKX2-5 are key players of the gene regulatory network governing cardiac differentiation. However, the mechanisms involved in their regulation and the decision making process of cardiac commitment are still not clear. RNA-seq results of human induced pluripotent stem cells (hiPSC) differentiated to cardiomyocytes (CM) revealed 2.208 regulated genes (p-adj
