SIGMA-1 RECEPTOR AGONIST PRE-084 ALTERS, IN TERMINAL BUT NOT IN EARLY ADOLESCENT FEMALE WISTAR RATS, ETHANOL-INDUCED CONDITIONED TASTE AVERSION, BUT DOES NOT AFFECT ETHANOL BINGE DRINKING

SALGUERO, AGUSTÍN; MARENGO, LEONARDO; PORTILLO-SALIDO, ENRIQUE; CENDÁN, CRUZ MIGUEL; MORÓN, IGNACIO; RUIZ-LEYVA, LEANDRO; PAUTASSI, RICARDO MARCOS

Congreso; XXXVI Annual Meeting (SAN2021); 2021

Sociedad Argentina de Neurociencias

Previous research shows reduced sensitivity to the aversive effects of alcohol in adolescence relative to adults. Moreover, recent work has suggested that aversive effects of ethanol are greater in late adolescence than in early adolescence but few studies have assessed the role of the different transmitter systems in these ontogenetic differences and even less in females. It is known that Sigma-1 Receptors (S1R) are involved in several manifestations of alcohol addictions such as ethanol drinking and conditioned taste aversion (CTA) which can be considered as a behavioral index of ethanol´s motivational properties. We found that pretreatment with the selective S1R agonist PRE-084 (32 mg/kg) altered ethanol(1,75 g/kg)-induced conditioned taste aversion (CTA) at late adolescence in female wistar rats but failed to affect ethanol(2,25 g/kg)-induced CTA at early adolescence. The effect of S1R agonism by PRE-084 (32 mg/kg) on binge ethanol intake was assessed at terminal adolescence. S1-R activation at the acquisition of ethanol induced CTA facilitated the extinction of such learning at terminal but not at early adolescence. PRE-084 did not significantly affect ethanol binge drinking in the terminal adolescents. The current report highlights the role of S1-R in ethanol-induced CTA and suggests that differential functionality of this transmitter system may underlie age-specific sensitivities to the aversive effects of ethanol.