Multivariate analysis of immune cells populations involved in tumor growth

ANTONELA DEL GIÚDICE,; MARÍA CELESTE CAPITANI, ; MATÍAS FUSINI, ; LEANDRO MAINETTI, ; O. GRACIELA SCHAROVSKY, ; RICARDO DI MASSO, ; MARÍA JOSÉ RICO, ; ROZADOS VR

Congreso; LXIII Reunión Anual de SAIC, LXVI SAI; SAFIS; 2018

M-406 mammary adenocarcinoma appeared in an inbred CBi mouse. CBi- mice were artificially selected by body conformation from CBi. When CBi- mice are s.c. challenged with M-406, 100% of the tumors are rejected; conversely, tumor grows exponentially in CBi. To explain the participation of the immune system in this behavior, CBi and CBi- females (N=9), were inoculated with M-406, blood samples were taken on days 0, 7 and 14, and CD4+, CD8+, Treg and Th17 cells were quantified (flow cytometry). Day 0- CD4+: CBiCBi- (P=0.002), Treg: CBi>CBi- (P