METABOLIC SYNDROME: DEVELOPMENT OF A NEW MURINE MODEL

BARRANCO MM, ; HABIB MJ, ; DI CARLO B,; SIGAL N, ; SYLVESTREBEGNIS M, ; ZECHINATTI F, ; DEL GIUDICE A, ; RICO MJ, ; ROZADOS VR,; SCHAROVSKY OG,; VILLANUEVA SSM,; MAINETTI LE ; GARCÍA F

LXIII Reunión Anual de SAIC, LXVI SAI; SAFIS

Congreso; LXIII Reunión Anual de SAIC, LXVI SAI; SAFIS; 2018

The metabolic syndrome (MetS) is a serious health problem characterized by insulin resistance, dyslipidemia and central obesity. There is a strong correlation between obesity and increased risk for development MetS. Animal models are very useful tools in biomedical investigation. Diet-induced obesity models are used to develop MetS models. CBi is an inbred mouse strain generated by crossing BALB/c, Rockland, NIH and Swiss mice in the Institute of Experimental Genetics, School of Medical Sciences, UNR. Our aim was to emulate a model of MetS in CBi mice. Five weeks old male mice were randomly fed with a high fat diet containing 40% kcal from bovine fat (HFD group) or standard diet (Control group) (n=8/group). At week 16, body weight (BW) gain, showed higher values in HFD (%; 97±32) respect to Controls (54±2) (P