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BERGERO GastÓn
congresos y reuniones científicas
Título:
HIF-1/CD73 REGULATORY PATHWAY DETERMINES CHRONIC INFLAMMATORY RESPONSE AND TISSUE DAMAGE IN AN EXPERIMENTAL MODEL OF TRYPANOSOMA CRUZI INFECTION
Autor/es:
BERGERO GASTÓN; EBERHARDT NATALIA; MAZZOCO YANINA; JUAN MLADIN; FERNANDO ALFONSO
Reunión:
Congreso; REUNIÓN DE SOCIEDADES DE BIOCIENCIAS 2020; 2020
Institución organizadora:
REUNIÓN DE SOCIEDADES DE BIOCIENCIAS 2020
Resumen:
The transcription factor HIF-1 regulates the expression of the CD39 and CD73 ectonucleotidases, which drive the catabolism of the pro-inflammatory molecule ATP towards the anti-inflammatory mediator adenosine. We have reported that CD73 activity has a tissue-dependent impact on the host immune response against acute Trypanosoma cruzi infection. Here, we explored the effect of CD73 deficiency (CD73KO) on immune cells infiltrating target tissues during chronic T. cruzi murine infection. Through flow cytometry, we found that CD73KO mice exhibited higher CD4/CD8 ratio in peripheral blood (p
