LSP1 KO TUMOR-BEARING MICE HAVE A HIGHER FREQUENCY OF FUNCTIONAL CROSS-PRESENTING DENDRITIC CELLS IN THE SPLEEN

PASCUAL, MARÍA MERCEDES; DHO, NICOLÁS DANIEL; ACLAND STRACK, RACHEL PAOLA; CRESPO, MARÍA INÉS; PISTORESI, MARÍA CRISTINA; MALETTO, BELKYS ANGÉLICA; MORÓN, VÍCTOR GABRIEL

Mar del Plata

Congreso; REUNIÓN SAI-SAIC-SAFIS; 2018

All leukocytes and endothelial cells from human and mice expressa 52kDa cytoplasmic F-actin binding phosphoprotein, calledLeukocyte-specific protein 1 (LSP1). This protein is known as animportant actin cytoskeleton-regulator. LSP1 polymorphisms ordownregulation are considered risk factors for some types of cancer.Using the MO5 melanoma model, our group has shown thatLSP1 deficient mice have an impaired control of melanoma growth.In order to study the role of LSP1 in antitumor immune response,WT and Lsp1-/- mice were subcutaneously-injected with 105MO5cells and followed-up until day 15 or 17 depending on the experiment.At these time points, tumors in Lsp1-/- mice were bigger thanin WT controls (p