Intramuscular Drug Delivery

SCIOLI MONTOTO, SEBASTIÁN; RUIZ, MARÍA ESPERANZA

The ADME Encyclopedia. A Comprehensive Guide on Biopharmacy and Pharmacokinetics

Springer Nature

Lugar: Basignstoke; Año: 2021;

Administration of drugs by the intramuscular route consists in the injection of a pharmaceutical dosage form (solution, suspension or emulsion), through the skin, into a muscle of the body. It is among the parenteral routes of drug administration and is often abbreviated IM administration.This administration route is, together with the subcutaneous (SC) and the intravenous route (IV), one of the three most used parenteral routes of drug administration. They share the common feature of invasiveness, since administration is always performed through the skin, by means of a needle or a cannula. However, only the IV route delivers the drug directly into the bloodstream. SC and IM administration, on the other hand, inject the dosage form into some tissue (subcutaneous fat or a muscle, respectively) from which the drug must be absorbed to reach systemic circulation.