THYMIC EXPORTATION AND EFFECTOR FUNCTION OF MEMORY-LIKE CD8+ T CELLS

VIANO, MARIA ESTEFANIA; BAIGORRÍ, RUTH ELIANA; STEMPIN, CINTHIA CAROLINA; PEREZ, ANA ROSA; DI NATALE, BRENDA; PACINI, FLORENCIA; BULFONI-BALBI, CAMILA; GONZALEZ, FLORENCIA; LIDON, NICOLÁS LEONEL; CERBÁN, FABIO MARCELO; RODRIGUEZ-GALAN, MARIA CECILIA

Mar del Plata

Congreso; Reunión anual de sociedades de biociencias SAIC. SAI. SAFIS; 2022

Memory-like cells are a subset of CD8+ T cells that present a memory phenotype without previous antigen encounter. They are a heterogeneous group of cells compose of innate CD8+ T cells that arise in the thymus (TIM) and are exported to secondary lymphoid organs (SLO) or, could develop directly in SLO where are named as virtual CD8+ T cells (TVM). TVM/TIM rapidly respond to IL-12 and IL-18 and play a protective role during the early phase of bacteria, viral and parasite infections. We have previously reported that thymi from Trypanosoma cruzi (Tc)-infected mice are highly enriched on TIM. TVM/TIM can be distinguished from conventional memory T cells (TMEM)by their low expression of CD49d. While residing in the thymus, phenotypic analysis in OT-I mice demonstrate that OVA tetramer+ (OVAt+) single positive CD8 (SP8) cells (not specific for the parasite) expressed higher levels of CD44, CD122, CD5, CD69, Qa2 and decreased levels of CD24 compared to conventional polyclonal SP8 cells (p