Light influence on Acinetobacter lifestyle and pathogenesis

TUTTOBENE, MARISEL ROMINA; GOLIC, ADRIÁN; MUSSI, MARÍA ALEJANDRA

Conferencia; AcinetoVibes 2020; 2020

we have shown that light exhibits a global effect in the physiology of the human pathogen Acinetobacter baumannii. In particular, we have presented evidence that light modulates processes associated with its pathogenicity such as the formation of biofilms, motility and virulence against eukaryotic hosts such as Candida albicans, and even susceptibility to certain antibiotics. Recently, we identified new traits whose expression are modulated by light in this pathogen such as the PAA catabolic pathway, trehalose biosynthesis, acetoin degradation, and also clusters related to lipid metabolism, bacterial competition such T6SS and tolerance to antibiotics, and determined that these responses depended on the BLUF photoreceptor BlsA