Molecular mechanisms of airborne hospital environment adaptation from Acinetobacter sp. 5-2AC02

LAURA FERNANDEZ GARCIA; F. FERNANDEZ-CUENCA; L. BLASCO; M.LOPEZ; L. MARTINEZ-MARTINEZ; A. PASCUAL; TUTTOBENE, MARISEL R.; MUSSI, MARÍA ALEJANDRA; G. BOU; M. TOMÁS

Madrid

Congreso; 28th European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2018); 2018

Acinetobacter species has been classified as one of the most dangerous nosocomial pathogens in the world. Nowadays, several studies have focused on the analysis of the adaptation capacity of this pathogen under stress conditions. In this work, we have studied the molecular mechanisms, associated to environmental adaption, of airborne Acinetobacter sp. 5-2Ac.02 (close to A.towneriispecies; Genbank-Accesion-Number MKQS00000000). Founding an overexpression of several genes involved in stress response under Mitomicin C presesnce; and theactivation of an acetoin degradation cluster, in the presence of signals from the Quorum network. This cluster lacks, in this strain, one of its transcriptional regulators. Interestingly, Acinetobacter sp. 5-2Ac02 strain showed its important capacity of degradation of the acetoin (15mM) independently of the inhibition of the QS system by darkness (Quorum network by light).